货号: R26445
别名: activating transcription factor 6; ATF6A
应用: WB,IHC-P,IP
反应种属: Human
目录价格:
RMB(含税报价)
数量: - + (库存件)
查看代理商 预计货期:现货 说明书PDF
产品详情
  • Product Name
    ATF6 Rabbit mAb
  • Background
    This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
  • Alternative Names
    activating transcription factor 6; ATF6A
  • Immunogen
    Recombinant protein of human ATF6
  • Buffer System
    50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
  • Dilution Ratio
    WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20
  • Molecular Weight
    Calculated MW: 75 kDa; Observed MW: 90-100 kDa
  • Gene Name
    ATF6
  • Host
    Rabbit
  • Reactivity
    Human
  • Conjugation
    Unconjugated
  • Application
    WB,IHC-P,IP
  • Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • SwissProt ID
    P18850
  • Purification
    Affinity Purified
  • Clonality No.
    R05-4E7
  • Clonality
    Monoclonal Antibody
  • Isotype
    IgG
  • Antibody Type
    Primary Antibody
  • Form
    Liquid
  • Source
    Human
  • Research Field
    Epigenetics and Nuclear Signaling
  • Gene ID
    22926
验证详情

应用缩写

WB:蛋白质印迹法IHC-P:石蜡切片样本的免疫组织化学法IHC-F:冰冻切片样本的免疫组织化学法ICC/IF:免疫细胞荧光 IP:免疫沉淀法FC:流式细胞术ChIP:染色质免疫沉淀法ELISA:酶联免疫吸附测定 正能生物产品售后保障范围仅限官网产品详情页中“应用”一栏写明的实验应用,请参照上方的缩写含义,仔细对照后选择合适的产品。
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