凋亡核心-Caspase家族

总的来说,细胞凋亡的调节大致可以分为Caspase依赖的和不依赖的两类。对Caspase的抑制,大多只能延缓细胞凋亡的过程,并不能完全避免凋亡的发生。但是对于凋亡研究来说,Caspase仍然是其核心机制分子。Caspase家族包含多种蛋白,其中Caspase-1Caspase-4主要负责白介素前体的活化,并不直接参与凋亡信号的传递。被称为凋亡启动蛋白的Caspase-2, -8, -9, -10-12主要负责对执行者的前体进行切割,从而产生有活性的效应蛋白。Caspase-3, -6-7则可以直接切割细胞核内或细胞质中的结构蛋白和调节蛋白,以执行凋亡程序。一般来说,PARPLamin A/C等靶蛋白可被活化的Caspase剪切,随后成为凋亡的标记,ROCK被切割后则会影响质膜稳定性,促进凋亡的发生。


凋亡相关靶标产品货号精品抗体重组兔单抗产品名称反应种属应用
死亡受体相关R24283Fas Rabbit mAbHumanWB,IHC-F,IHC-P,ICC/IF
501540

TNF Receptor 1 Rabbit pAbHuman,Mouse,RatWB,IHC-P
200822
TNFRSF10B (7F4) Mouse mAbHuman,MouseWB,ICC/IF
R24275FADD Rabbit mAbMouse,RatWB,IP
820622

FADD Rabbit pAbHuman,MouseWB,IHC-P,ELISA
R25279PARP1 Rabbit mAbHuman,Mouse,RatWB,IHC-F,IHC-P,ICC/IF
380374
Cleaved-PARP1 Rabbit pAbHumanWB,ICC/IF,IP,FC
R24823Lamin A/C Rabbit mAbHuman,Mouse,RatWB,IHC-F,IHC-P,ICC/IF,IP
R24647ICAD Rabbit mAbHuman,RatWB
R25607ROCK1 Rabbit mAbHuman,Mouse,RatWB,IP
R22622ROCK2 Rabbit mAbHuman,RatWB,ICC/IF
caspase凋亡启动子381055

Caspase 2 Rabbit pAbHuman,Mouse,RatWB,IHC-P,ICC/IF,FC
250106
Caspase 8 (2G12) Mouse mAbHuman,Mouse,RatWB,IHC-F,IHC-P,ICC/IF
R22844Caspase 9 Rabbit mAbHuman,MouseWB,IP
381238

Cleaved-Caspase 9 Rabbit pAbHuman,MouseWB,IP
R23723Caspase 10 Rabbit mAbHumanWB,IHC-P,IP
160136

Caspase 12 Rabbit pAbHuman,MouseWB,IHC-P,ELISA
caspase凋亡效应器R23315Caspase 3 Rabbit mAbHuman,Mouse,RatWB,IHC-P,IP
380169
Cleaved-Caspase 3 p17 Rabbit pAbHumanWB,IHC-P,ICC/IF
R26517Caspase 6 Rabbit mAbHumanWB,IHC-P
341036

Cleaved-Caspase 6 p18 Rabbit pAbHuman,RatWB,IHC-P,ELISA
R26518Caspase 7 Rabbit mAbHuman,Mouse,RatWB,IHC-P
R27200Caspase 7 Rabbit mAbHumanWB,IHC-P
caspase其他蛋白381016
Caspase 1 Rabbit pAbHuman,RatWB,IHC-P
341030
Cleaved-Caspase 1 Rabbit pAbHumanWB,ICC/IF,IHC-F,IHC-P,ELISA
381294

Caspase 5 Rabbit pAbHumanWB,IHC-P,ICC/IF,IP
347416

Cleaved-Caspase 4/5 p20 Rabbit pAbHumanWB,ELISA
R23724Caspase 11 Rabbit mAbMouseWB,IP
线粒体相关R22867Cytochrome C Rabbit mAbHuman,Mouse,RatWB,IHC-P,IP
380882

APAF1 Rabbit pAbHuman,MouseWB,IHC-P,ICC/IF
201149-8H1
AIF (8H1) Mouse mAbHumanWB,ICC/IF
382307

Endo G Rabbit pAbHuman,Mouse,RatWB
R26117XIAP Rabbit mAbHuman,Mouse,RatWB
R25739SMAC Rabbit mAbHuman,Mouse,RatWB,IHC-F,IHC-P,ICC/IF,IP
381426
ATF4 Rabbit pAbHuman,Mouse,RatWB,IHC-P,ICC/IF,IP,FC
应激,DNA损伤相关R23316DDIT3 Rabbit mAbHuman,Mouse WB,IHC-P
381868

Calpain 1 Rabbit pAbHuman,Mouse,RatWB,IHC-P,ICC/IF,FC
R24780JNK Rabbit mAbMouse,RatWB,ICC/IF,IP
R26311Phospho-JNK1 (Thr183/Tyr185) Rabbit mAbHumanWB,IP
R25247p53 Rabbit mAbHumanWB,ICC/IF



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